A single center longitudinal study of factors associated with progression of stage 3 and 4 chronic kidney disease in children.
DOI:
https://doi.org/10.56867/34Keywords:
Nephrosis, Lipoid, Glomerular Filtration Rate, Renal Insufficiency, Chronic, Disease Progression, ChildAbstract
Introduction: Chronic kidney disease (CKD) has a natural evolution toward the loss of progressive kidney function; however, there is controversy about whether the progression has a constant and predictable rhythm. The objective of the present study was to identify the risk factors associated with progression in a group of children with CKD.
Methods: This longitudinal study was conducted in a follow-up of children under 16 years of age diagnosed with CKD in stages 3 and 4 at the Hospital de Pediatría, Centro Médico Nacional Siglo XXI, from October 2014 to October 2015. Somatometry, blood pressure, creatinine, hemoglobin, cholesterol, triglycerides, phosphorus, bicarbonate, proteinuria, and CKD progression were measured. The sample is compared between those who presented progression (P-ERC) and those who did not (SP-ERC). Values with medians are given.
Results: A total of 35 patients were ten years old, 18 women (54.4%), and 57% had urinary tract malformations. After follow-up for 2.95 years, the glomerular filtration rate (GFR) was 31.7 ml/min/1.73 m2. In stage 3, 20 patients were 8.7 years old, and 60% were women. In stage 4, 15 patients were 11.4 years old, and 66.7% were men. The decrease in GFR was 6.7 ml/min/1.73 m2/year, 6.6 for stage 3, and 2.8 for stage 4. Cholesterol levels were associated with the progression of kidney damage (P=0.03). Other factors were not significant. In both groups, the number of patients with obesity increased (P>0.05).
Conclusion: In the first year, 50% of the patients had P-CKD. Stage 3 patients have a higher velocity P-CKD. Hypercholesterolemia is a factor in the progression of CKD in children.

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Copyright (c) 2022 Alma Rebeca Mota Nova, María Alejandra Aguilar Kitsu, Miguel Angel Villasis Keever (Author)

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