Relationship between histopathological patterns with clinical diagnosis in pediatric patients with renal disorders.
A single-center observational study, 4- year follow-up.
DOI:
https://doi.org/10.56867/19Keywords:
Nephrosis, Lipoid, Glomerular Filtration Rate, Renal Insufficiency, Chronic, Disease Progression, ChildAbstract
Introduction: Glomerulopathies in children may not be correlated with the degree of glomerular filtration or the intensity of proteinuria as it occurs in adults. The objective of the present study was to describe the histopathological characteristics of renal biopsies performed in a pediatric population with glomerulopathies and to correlate them with the clinical presentation.
Methods: This observational study was conducted at the Baca Ortiz Pediatric Hospital (Quito) from January 2016 to July 2019. Children with glomerulopathies diagnosed with renal biopsy were included. The variables were clinical diagnosis, histological pattern, age, sex, ethnicity, urea, creatinine, proteinuria, and renal ultrasound. The sample was non-probabilistic. Descriptive statistics were used, and Cramer's V test was used to determine the degree of association.
Results: In 57 cases, 29 (50.9%) were men. The presence of azotemia occurred in 45.6% of the cases. Nephrotic range proteinuria in 47% of cases. The average glomerular filtration rate was 116 ml/min. The most prevalent glomerulonephritis was membranoproliferative (29.8%), with endocapillary and lupus glomerulonephritis accounting for 50% of the sample. Postinfectious glomerulopathy (PGIP) 29 cases (50.9%); Nonproliferative primary glomerulonephritis GMINOP 9 cases (15.8%) and secondary glomerulopathy (GPII) 18 cases (31.6%). There was no association with clinical syndromes (P>0.05).
Conclusions: No relationship exists between histopathological patterns and clinical diagnosis in the sample analyzed in pediatric patients. Primary proliferative glomerulopathies represent little more than half of the renal pathology biopsied.

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Copyright (c) 2022 Wilmer Stalin Sanango Reinoso, Junior Rafael Gahona Villegas, Jorge Manuel Pérez Galarza (Author)

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