Relationship between histopathological patterns with clinical diagnosis in pediatric patientPreeclampsia-eclampsia as a risk factor for the development of chronic kidney disease: A single-center observational study, 11 years of follow-up.
DOI:
https://doi.org/10.56867/31Keywords:
Eclampsia, Pre-Eclampsia, Renal Insufficiency, Chronic, Proteinuria, Hypertension, HematuriaAbstract
Introduction: Preeclampsia-eclampsia is a prevalent systemic disorder of pregnancy characterized by hypertension and proteinuria, a sign of renal dysfunction. Little is known about its long-term effects on the kidney, either in terms of physical damage measured by albuminuria or proteinuria, development of chronic arterial hypertension, functional impairment measured by reduced glomerular filtration rate, or end-stage renal failure.
Methods: In the present analytical and retrospective study, data were taken from the medical records of patients with a history of preeclampsia-eclampsia treated in the gynecology and obstetrics service of the Hospital de Especialidades Carlos Andrade Marín diagnosed from January 2008 to December 2018 (group exposed), and healthy pregnant women during the same period (non-exposed group), once randomized, follow-up is performed to establish the prevalence of some degree of chronic kidney disease in the groups.
Results: 201 cases were included in the preeclampsia group (GPE) and 201 in the control group (CG). Age of 29.5 ± 6.8 years in GPE and 31.4 ± 6.5 in CG, P=0.30. Hispanic ethnicity 191 (95.0%) in GPE and 196 (97.5%) in CG, P=0.90. Higher education is in 93 (46.3%) of GPE and 94 (46.8%) of CG. CKD (Stage 1-5) OR=3.725 (95% CI 1.935 – 8.381), P=0.0002. CKD (Stage 5) OR=1.764 (0.75 – 239.5), P=0.077. Mestizo ethnicity OR= 3.911, (95% CI 2.21 – 10.91) P=0.0001. Development of arterial hypertension 2.041 (CI95% 1.038 – 6.317) P=0.0413. Development of proteinuria OR= 2.193 (95% CI 1.164 – 15.083) P=0.0283.
Conclusions: Women with a history of preeclampsia-eclampsia in their pregnancies had a higher risk of developing any degree of CKD.

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Copyright (c) 2022 Norlys Margoth Fontalvo Díaz, Boris Marcelo Torres Zavala, Jorge Washington Vélez Páez (Author)

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