Proteinuria/creatinuria index related to preeclampsia with signs of severity in patients.

A single-center observational study.

Abstract

Introduction: Preeclampsia is a common hypertensive disorder in pregnant women, whose impact varies depending on its severity and can affect target organs such as the kidneys. The proteinuria/creatinuria index is a test that can be performed in pregnant patients to corroborate the existence of significant proteinuria, which could be found within the diagnosis of preeclampsia. The objective of the study was to determine the association between the proteinuria/creatinuria index and women with signs of severity in preeclampsia.

Methods: observational, analytical, retrospective study. The data were taken from the José Carrasco Arteaga Specialty Hospital database in Cuenca-Ecuador between January 2017 and December 2021. The statistical analysis used the SPSS 25 program and Microsoft Excel 2018. The association between variables was evaluated with the chi-square test and calculation of odds ratios.

Results: 149 cases were included, the mean age was 31.9 ± 5.5 years, 49% were married, and 64.4% were from the urban area. 35.7% were nulliparous, with the average gestational age being 34.6 ± 4.2 weeks. The universe consisted of 149 preeclamptic patients, of which 86.6% (n=129) presented signs of severity. The median proteinuria/creatinuria ratio was 0.58 (0.26-1.66) mg/dL. The proteinuria/creatinuria index was not associated with preeclampsia with signs of severity (X²=2.161; OR=2.547; 95% CI=0.706- 9.186; P=0.153).

Conclusion: This study's proteinuria/creatinuria index was not associated with preeclampsia with signs of severity.