Phosphorus kinetics in patients with chronic renal failure on hemodialysis.
DOI:
https://doi.org/10.56867/13Keywords:
Renal Dialysis, Hemodiafiltración, Kinetics, Phosphorus Metabolism Disorders, HyperphosphatemiaAbstract
Introduction: Hyperphosphatemia is one of the factors associated with high mortality in patients with chronic renal failure in dialysis programs. The objective of the present study was to perform intra- and post-dialysis serum phosphorus (P) kinetics, taking into account factors such as dialysis time and extracorporeal flow (Qs).
Methods: This cross-sectional study was conducted from September 2018 to January 2019. Baseline phosphate levels were analyzed at 60, 120, 180, and 240 intradialytic and 1 and 2 hours post-hemodialysis. A descriptive analysis was performed. Linear regression was performed to determine factors associated with post-hemodialysis serum P levels.
Results: 56 patients were included, 48 ± 13 years old, 30 women (53%), 46 with a catheter (82%), and 27 (48%) received treatment for 240 minutes. Qs of 300 ml/min in 11%, 350 ml/min in 65%, and 400 ml/min in 26% of cases. pH 7.3 ± 0.6, Hemoglobin 9.4 ±1.6 gr/dL. Basal P, at 60, 120, 180, and 240 minutes, was 5.3, 3.5, 2.9, 2.7, and 2.6 mg/dl, respectively. The P at 60 and 120 minutes post-HD were 3.5 and 3.75 mg/dl, respectively. Factors associated with the phosphorus level at 120 min post hemodialysis were hemoglobin P=0.004, Standardized beta coefficient (CBE) 0.247 (95% CI 0.04-0219), and phosphorus removal at 240 min P=0.001, CBE=0.503, (CI95% 0.265-0.905).
Conclusions: The decrease in phosphate in the study group was 50.9%, with a rebound elevation at 2 hours of 21.82%. Hemoglobin above 11 gr/dl is a factor associated with hyperphosphataemia. The intensity of phosphorus removal at 240 minutes is associated with serum phosphorus levels.

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Copyright (c) 2022 Juan Manuel Duran, María Inés Gil Arredondo , Pedro Trinidad Ramos (Author)

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