Determination of Cystatin C as a marker of renal function in normoalbuminuric patients with type 2 Diabetes Mellitus.

A multicenter study.

Abstract

Introduction: Early identification of impaired renal function is crucial in diabetic patients. Clinically, serum cystatin C could be the most sensitive indicator of glomerular filtration rate. The present study's objective was to propose using cystatin C as a routine test to evaluate renal function in type 2 diabetic patients.

Methods: An observational cross-sectional study on 115 normoalbuminuric type two diabetic patients, establishing the glomerular filtration rate with cystatin C values and the Cockroft-Gault formula. Those with a glomerular filtration rate < 60 mL/min underwent 24-hour urine creatinine clearance. We compared the results with the statistical program SPSS 17, presenting the data in contingency tables with risk analysis and significance test of X2

Results: The glomerular filtration rate obtained with cystatin C had an average value of 99 ± 19.07 ml/min/1.73 square meters of body surface (SMS). The Cockroft-Gault value was 79.85 ± 23.63 ml/min/1.73 sms, reflecting a better correlation with creatinine clearance in 24-hour urine, which was 74.95 ± 37.41 ml/min/1.73 sms. Both parameters had no significant relationship when relating the values to the 24-hour urinary creatinine clearance (P = 0.14).

Conclusions: The glomerular filtration rate with cystatin C presents a significant dispersion in the correlation with the creatinine clearance in the urine for 24 hours; this fact, together with various factors that influence its variability, and the higher cost of its determination, make its use to assess renal function little justifiable.